Compounded Semaglutide Dosage Chart: Unit Calculations

You have a vial of compounded semaglutide. Your provider prescribed your dose in milligrams. Your vial label shows a concentration in mg/mL. Here is how these pieces fit together and how to draw the correct dose.

Compounded semaglutide is fundamentally different from brand-name semaglutide auto-injectors. Those come pre-filled and pre-dosed. You press a button, and a precise amount is delivered. Compounded semaglutide comes as a vial of liquid at a specific concentration. You use a syringe to draw the volume your provider prescribed. Understanding your vial concentration is everything.

How compounded semaglutide differs from brand-name versions

Brand-name semaglutide auto-injectors are manufactured by a pharmaceutical company and FDA-approved. Each auto-injector is pre-filled with a specific dose. You do not measure or calculate. You inject the entire contents of the pen.

Compounded semaglutide is prepared by licensed US compounding pharmacies. It comes as a multi-dose vial at a specific concentration. The concentration tells you how many milligrams of active semaglutide are dissolved in each milliliter of liquid. Because the medication is not pre-dosed, you (or a provider) draw the correct volume based on your prescribed milligram dose and your vial’s concentration.

Both deliver semaglutide as the active ingredient. Both follow similar escalation schedules for weight management. The difference is in the format and how you administer each dose.

Understanding vial concentrations

Compounded semaglutide comes in different concentrations. The most common are 2.5mg/mL and 5mg/mL. Some pharmacies use other concentrations like 2mg/mL or 10mg/mL, but these are less common for semaglutide weight-management dosing.

Your vial label will print the concentration clearly. It looks like this:

Semaglutide 2.5mg/mL means: 2.5 milligrams of semaglutide in 1 milliliter of liquid.

Semaglutide 5mg/mL means: 5 milligrams of semaglutide in 1 milliliter of liquid.

The higher the concentration, the smaller the volume you need to draw for the same dose. This is why someone using 5mg/mL vials draws less liquid than someone using 2.5mg/mL vials, even if they are at the same dose in milligrams.

Before drawing any dose, look at your vial label and confirm the concentration. Do not guess. Do not assume. If your label is unclear or missing, contact your pharmacy immediately.

How to calculate your dose

The calculation is straightforward:

Volume (mL) to draw = Prescribed dose (mg) divided by vial concentration (mg/mL)

Once you know the milliliters to draw, you convert that to units on a standard U-100 insulin syringe:

Units on syringe = mL to draw multiplied by 100

Example: 0.5mg dose at 2.5mg/mL concentration

• Volume = 0.5 mg divided by 2.5 mg/mL = 0.2 mL
• Units = 0.2 mL x 100 = 20 units

You draw to the 20-unit mark on a U-100 syringe.

Example: 0.5mg dose at 5mg/mL concentration

• Volume = 0.5 mg divided by 5 mg/mL = 0.1 mL
• Units = 0.1 mL x 100 = 10 units

You draw to the 10-unit mark on a U-100 syringe.

Same dose in milligrams, different vial concentration, different unit amounts. This is why knowing your exact concentration is critical.

Compounded semaglutide dosage tables

Below are complete reference tables for the two most common concentrations. Find your vial concentration, locate your prescribed dose, and use the chart to determine how many units to draw on your syringe.

Semaglutide at 2.5mg/mL concentration

This is the most common concentration used for compounded semaglutide in weight-management programs.

Semaglutide at 5mg/mL concentration

This concentration delivers the same doses in smaller volumes, requiring more precision when drawing small amounts.

Standard semaglutide escalation schedule

Compounded semaglutide for weight management typically follows the same escalation pattern as branded protocols^[1]. Most patients start at 0.25mg and increase every 4 weeks, but your provider may adjust timing based on side effects or your individual response.

• Weeks 1-4: 0.25mg once weekly
• Weeks 5-8: 0.5mg once weekly
• Weeks 9-12: 1mg once weekly
• Weeks 13-16: 1.7mg once weekly
• Week 17 and beyond: 2.4mg once weekly

Not all patients escalate to the maximum dose. Some stop at 1mg or 1.7mg because their appetite is controlled or side effects are limiting. Your provider determines your optimal dose based on your labs, response, and goals. Never increase your dose on your own or skip ahead in the schedule.

How to read a U-100 insulin syringe

A U-100 syringe is marked to hold up to 100 units of medication in 1 milliliter. Each unit equals 0.01mL.

The barrel has major numbered marks at 10-unit intervals (10, 20, 30, 40, etc.). Between each number are smaller lines representing individual units. When you draw your dose, pull the plunger back until the top of the plunger lines up with the correct unit marking.

For doses that fall between major lines (like 68 units), position the plunger between the two closest marks. For 68 units, the plunger is 8 tenths of the way between the 60 and 70 mark. Do your best to be as accurate as possible.

Small doses (like 5 units) are harder to measure precisely because the plunger is barely pulled back. If accuracy is difficult for you, mention it to your provider or pharmacist.

Critical safety checks before every injection

Before you inject, verify three specific things. This takes 30 seconds and prevents serious dosing errors.

Check 1: Verify your vial concentration. Look at your vial label right now. What does it say? 2.5mg/mL? 5mg/mL? Write it down. Match it to the correct concentration table on this page.

Check 2: Verify your prescribed dose. Check your provider’s prescription paperwork, email, or app. What dose are you supposed to inject this week? Write it down. Find that dose in the correct row of the table for your vial concentration.

Check 3: Verify your unit amount. After you draw your dose, the plunger should match the unit number from your table. If your dose is 0.5mg and your vial is 2.5mg/mL, your syringe should show 20 units. If it shows something else, you may have miscalculated or grabbed the wrong vial. Stop. Do not inject. Contact your care team.

If any of these three do not line up exactly, do not inject. Contact your provider or pharmacy.

Important: Never self-adjust or share your vial

Your provider prescribed a specific dose for your body, labs, and medical history. Do not increase your dose faster than prescribed or jump to a higher escalation step on your own. Do not skip weeks or slow down the schedule without talking to your provider first.

Never share your medication or vial with anyone else, even if they think they need the same dose. Each prescription is specific to that person’s health profile.

Oral semaglutide vs. injectable: Different measurements

If you have oral semaglutide (a tablet or sublingual preparation), the dosing on this page does not apply. Oral semaglutide is measured in milligrams per tablet and is not converted to units. Your prescription will specify a tablet strength like 7mg or 14mg daily. No syringe, no volume calculation, no units.

If you are unsure whether you have injectable or oral semaglutide, check your prescription label and packaging. Injectable comes as a vial with a syringe. Oral comes as a tablet, capsule, or strip.

Transformation Health compounded semaglutide programs

Transformation Health connects you with independent, licensed providers who prescribe compounded semaglutide when medically appropriate. Injectable semaglutide is $249 per month. All-inclusive pricing covers your medication, lab work (Quest or Labcorp), and medical weight loss coaching. No hidden fees. Cancel anytime.

Your provider reviews your health history, determines whether semaglutide is appropriate for you, and prescribes a dose specific to your needs. Your medication is prepared by a licensed US compounding pharmacy and shipped directly to you with dosing instructions tailored to your vial concentration.

Residents of Arkansas, DC, Delaware, Mississippi, New Mexico, Rhode Island, and West Virginia must complete a live video consultation before a prescription can be written.

Citations

[1] Wilding JPH, et al. “Once-Weekly Semaglutide in Adults with Overweight or Obesity.” New England Journal of Medicine. 2021;384(11):989-1002. https://pubmed.ncbi.nlm.nih.gov/33567185/